Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: suggestions for appropriate observables |
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Authors: | Brown F L Leitner D M McCammon J A Wilson K R |
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Institution: | Department of Chemistry, University of California, San Diego, La Jolla, California 92093-0339 USA. flb@chem.ucsd.edu |
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Abstract: | We consider the possibility of inferring the nature of cytoskeletal interaction with transmembrane proteins via optical experiments such as single-particle tracking (SPT) and near-field scanning optical microscopy (NSOM). In particular, we demonstrate that it may be possible to differentiate between static and dynamic barriers to diffusion by examining the time-dependent variance and higher moments of protein population inside cytoskeletal "corrals." Simulations modeling Band 3 diffusion on the surface of erythrocytes provide a concrete demonstration that these statistical tools might prove useful in the study of biological systems. |
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