A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks |
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| Authors: | Williams R Scott Tainer John A |
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| Affiliation: | Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA. |
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| Abstract: | In a recent study (Moreno-Herrero et al., 2005), atomic force microscopy (AFM) imaging of the human Mre11/Rad50/Nbs1 (MRN) complex engaging substrate DNA revealed large-scale, DNA binding-induced propagation of conformational change to the distal ends of the Rad50 coiled coils and erection of a 1000 A scaffold to productively bridge DNA ends. |
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