The ins and outs of ATP-dependent chromatin remodeling in budding yeast: Biophysical and proteomic perspectives |
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Authors: | Joke JFA van Vugt Michael Ranes Coen Campsteijn |
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Institution: | a Department of Molecular Biology, NCMLS, Radboud University, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands b Sars International Centre for Marine Molecular Biology, Thormøhlensgt. 55, N-5008 Bergen, Norway |
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Abstract: | ATP-dependent chromatin remodeling is performed by multi-subunit protein complexes. Over the last years, the identity of these factors has been unveiled in yeast and many parallels have been drawn with animal and plant systems, indicating that sophisticated chromatin transactions evolved prior to their divergence. Here we review current knowledge pertaining to the molecular mode of action of ATP-dependent chromatin remodeling, from single molecule studies to genome-wide genetic and proteomic studies. We focus on the budding yeast versions of SWI/SNF, RSC, DDM1, ISWI, CHD1, INO80 and SWR1. |
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Keywords: | Nucleosome Chromatin SNF2 STH1 ISW1 ISW2 INO80 SWR1 CHD1 YFR038w |
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