Monensin and bile protein secretion. A tool to investigate hepatocyte intracellular vesicular polarity |
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| Authors: | A Casu M M Averame R Piemontese |
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| Affiliation: | Istituto di Patologia Generale, Università, Genova. |
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| Abstract: | Bile derived from monensin treated bile-fistula rats was analysed by SDS-polyacrylamide gels. Differences in proteins were observed for bands presumptively corresponding to transferrin, secretory-IgA and free secretory components after treatment with the ionophore. The results show that the secretion of proteins in bile is differentiated and asyncronous, confirming a polarity of the hepatocyte subcellular compartments. |
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