Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints |
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| Authors: | Kolja Gelse David Pfander Simon Obier Karl X Knaup Michael Wiesener Friedrich F Hennig Bernd Swoboda |
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| Institution: | Division of Orthopaedic Rheumatology, University of Erlangen-Nuremberg, Rathsberger Strasse 57, Erlangen 91054, Germany. kolja.gelse@web.de |
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| Abstract: | Introduction Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study
investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1α by 2-methoxyestradiol or dimethyloxaloylglycine
on the progression of osteoarthritis in murine knee joints. |
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