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Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera |
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| Authors: | Ave Tooming-Klunderud David P Fewer Thomas Rohrlack Jouni Jokela Leo Rouhiainen Kaarina Sivonen Tom Kristensen Kjetill S Jakobsen |
| Affiliation: | (1) Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway;(2) Department of Biology, Centre for Ecological and Evolutionary Synthesis (CEES), University of Oslo, 0316 Oslo, Norway;(3) Department of Applied Chemistry and Microbiology, University of Helsinki, Viikinkaari 9, P.O. Box 56, FIN-00014 Viikki Biocenter, Finland;(4) NIVA, Norwegian Institute for Water Research, 0411 Oslo, Norway;(5) Department of Biology, Microbial Evolution Research Group (MERG), University of Oslo, 0316 Oslo, Norway |
| Abstract: | BackgroundCyanobacteria produce a wealth of secondary metabolites, including the group of small cyclic heptapeptide hepatotoxins that constitutes the microcystin family. The enzyme complex that directs the biosynthesis of microcystin is encoded in a single large gene cluster (mcy). mcy genes have a widespread distribution among cyanobacteria and are likely to have an ancient origin. The notable diversity within some of the Mcy modules is generated through various recombination events including horizontal gene transfer. |
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