Adrenomedullin-like immunoreactivity in the rat hypothalamo-neurohypophysial tract. |
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| Authors: | Y Ueta Y Hara V S Setiadji T Isse I Shibuya K Kitamura K Kangawa H Matsuo T Eto Y Hattori H Yamashita |
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| Institution: | Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. |
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| Abstract: | Adrenomedullin-like immunoreactivity in the hypothalamo-neurohypophysial tract in colchicine-treated and hypophysectomized rats was examined by immunohistochemistry. Adrenomedullin-like immunoreactive (AM-LI) neurons were localized in the hypothalamic areas, including the paraventricular nuclei and the supraoptic nuclei. Abundant AM-LI fibers and varicosities were found in the hypothalamoneurohypophysial tract and the internal zone of the median eminence in the colchicine-treated and hypophysectomized rats, whereas in control rats few AM-LI fibers were observed. These results suggest that the axons of the AM-LI neurons in the hypothalamus may terminate in the neurohypophysis. |
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