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Reading DNA differently |
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| Authors: | Yahaloma Gat David G. Lynn |
| Abstract: | Product inhibition has provided the limiting barrier to efficient template-directed ligation and polymerization reactions. Here we review the attempts to circumvent this limitation and outline a traslation strategy that does overcome the barrier and allows the information encoded in DNA to be read and amplified into backbone-modified oligonucleotides. © 1998 John Wiley & Sons, Inc. Biopoly 48: 19–28, 1998 |
| Keywords: | template-directed synthesis oligonucleotide catalysts DNA translation backbone-modified oligonucleotides |