Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells |
| |
Authors: | C Schmid T Steiner E R Froesch |
| |
Institution: | Metabolic Unit, University Hospital, CH-8091 Zürich, Switzerland |
| |
Abstract: | Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGF I) stimulated the incorporation of 14C] glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGF I stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts. |
| |
Keywords: | Rat calvaria cell Osteoblast differentiation Alkaline phosphatase Insulin-like growth factor I |
本文献已被 ScienceDirect 等数据库收录! |
|