| 综述: 干细胞衰老的表观遗传调控 |
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| 引用本文： | 苑婷婷,杨济平,管娣,丁志超,刘光慧.综述: 干细胞衰老的表观遗传调控[J].生物化学与生物物理进展,2014,41(3):231-237. |
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| 作者姓名： | 苑婷婷 杨济平 管娣 丁志超 刘光慧 |
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| 作者单位： | 中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101,中国科学院生物物理研究所，生物大分子国家重点实验室，北京 100101 |
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| 基金项目： | 中国科学院干细胞与再生医学战略先导专项(XDA01020312)和国家自然科学基金(31222039, 81330008)资助项目 |
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| 摘 要： | 干细胞衰老理论认为,组织器官特异的成体干细胞随着衰老出现功能性衰退,从而导致组织器官生理功能的衰退甚至衰老相关疾病的发生.表观遗传机制通过精密调控基因表达,在成体干细胞的衰老过程中发挥着重要作用.近年来,机体衰老过程中成体干细胞的表观遗传调控已经成为衰老研究的热点.本综述主要总结了衰老过程中成体干细胞命运的表观遗传调控,并详细介绍了DNA甲基化与组蛋白共价修饰在成体干细胞衰老中的作用,以期为深入认识衰老本质、实现健康长寿提供启示.
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| 关 键 词： | 干细胞 衰老 表观遗传 |
| 收稿时间： | 2013/12/19 0:00:00 |
| 修稿时间： | 2013/12/19 0:00:00 |
Review: Epigenetic Regulation in Stem Cell Aging |
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| YUAN Ting-Ting,YANG Ji-Ping,GUAN Di,DING Zhi-Chao and LIU Guang-Hui.Review: Epigenetic Regulation in Stem Cell Aging[J].Progress In Biochemistry and Biophysics,2014,41(3):231-237. |
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| Authors: | YUAN Ting-Ting YANG Ji-Ping GUAN Di DING Zhi-Chao and LIU Guang-Hui |
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| Institution: | National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China,National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China,National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China,National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | Tissue and organ-specific adult stem cells degenerate progressively with age, resulting in compromised tissue homeostasis and occurrence of aging-associated diseases. Epigenetic mechanisms play a key role in controlling individual as well as stem cell aging by the regulation of global and/or specific gene expression. Here, we summarize the recent findings on how epigenetic modifications especially DNA methylation and histone modifications regulate stem cell fate during aging, which may open a promising avenue towards achieving the goal of healthy aging. |
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| Keywords: | stem cell aging epigenetics |
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