Chronic effects of ethanol on muscle metabolism in the rat |
| |
Authors: | Elisabeth B Cook Lutfat AY Adebiyi Victor R Preedy Timothy J Peters TNorman Palmer |
| |
Institution: | 1. Department of Clinical Biochemistry, King''s College of School of Medicine and Dentistry, Bessemer Road, London UK;2. Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London UK;3. Department of Biochemistry, University of Western Australia, Nedlands Australia |
| |
Abstract: | Chronic ethanol feeding in the rat is associated with a skeletal myopathy involving primarily type-II muscle fibers, which is recognised to be mediated via a specific impairment in protein turnover. This paper investigates whether the cause of this myopathy may be related to abnormalities in carbohydrate and lipid metabolism in different muscles. U-14C]Glucose metabolism was examined in two muscles with different fibre compsitions, the extensor digitorum longus (EDL) muscle, which contains predominantly type-II muscle fibres, and the soleus muscle, which is composed primarily of type-I muscle fibres. Feeding on the ethanol-supplemented Lieber-DeCarli liquid diet for 2 or 6 weeks was associated with profound distubances in glucose metabolism in both EDL and soleus muscles, particularly in relation to rates of glycogen and alanine formation. We discuss the importance of these metabolic changes in relation to the genesis of chronic alcoholic skeletal myopathy. |
| |
Keywords: | Skeletal muscle Glucose metabolism Glycogen Ethanol Insulin |
本文献已被 ScienceDirect 等数据库收录! |
|