Gallic acid-based indanone derivatives as anticancer agents |
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| Authors: | Saxena Hari Om Faridi Uzma Srivastava Suchita Kumar J K Darokar M P Luqman Suaib Chanotiya C S Krishna Vinay Negi Arvind S Khanuja S P S |
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| Affiliation: | aRain Forest Research Institute, Jorhat, India;bCentral Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Road, Lucknow 226 015, India |
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| Abstract: | Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC50 = 2.2 μM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 μg/ml, 258 μM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations. |
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| Keywords: | Gallic acid Indanones Anticancer Osmotic fragility HMQC |
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