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Aphidicolin does inhibit repair replication in HeLa cells. |
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| Authors: | F Hanaoka H Kato S Ikegami M Oashi M Yamada |
| Institution: | 1. Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan;2. Department of Agricultural Chemistry, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan;3. Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, Sakae-cho, Itabashi-ku, Tokyo 173, Japan |
| Abstract: | Aphidicolin was shown to be a specific inhibitor of eukaryotic DNA polymerase α. We have examined the effect of aphidicolin on repair synthesis as well as replication of HeLa cell DNA, and found that it inhibits not only DNA replication but also UV-induced DNA repair in hydroxyurea-arabinosyl cytosine treated cells. |
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