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Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells |
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| Authors: | Ken-ichi Horiuchi Hideo Tsurushima Berm Soo Kim Shu Qin Liu Kaoru Saijo Yasuo Saijo Toshihiro Nukiwa Nakao Nomura Masatoshi Matsumura Tadao Ohno |
| Affiliation: | (1) RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN) Institute of Applied Biochemistry, Japan;(2) Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba Science City, Japan;(3) Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;(4) Institute of Applied Biochemistry, Japan |
| Abstract: | Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed target cells was larger than those with live target cells. The results suggest that formalin-fixed tumor cells will be stable sources of tumor antigen for efficient autologous CTL expansion and be useful for adoptive immunotherapy of tumors. This revised version was published online in August 2006 with corrections to the Cover Date. |
| Keywords: | adoptive immunotherapy cytotoxic T lymphocyte formalin-fixed tumor cell |
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