Chronoavailability: a theoretical method of studying chronopharmacology |
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Authors: | B Hecquet |
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Abstract: | The optimum time of drug administration or the chronestesy of a biosystem can be theoretically determined by the integration of the function: (drug concentration)-(susceptibility of the biosystem) versus time. This integral called chronoavailability could be useful to design experiments for evaluation of chronopharmacologic effects in man. |
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