The effect of methylglyoxal on actin |
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| Authors: | L Fésüs L Muszbek K Laki |
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| Affiliation: | 1. Department of Clinical Chemistry, University School of Medicine, Debrecen, Hungary;2. National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20205, U.S.A. |
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| Abstract: | Studying the gelation of Ehrlich ascites tumor cell extracts at various methyglyoxal concentrations, an increase of the gelled protein fraction, composed mainly of actin, was found at 10?7 M to 10?5 M. When methylglyoxal was added to intact tumor cells, the filamentous portion of cytoplasmic actin was increased at 10?7 M to 10?6 M concentrations. Furthermore, certain functional properties of purified skeletal muscle actin were also affected by μM concentrations of methylglyoxal; the speed of actin polymerization was facilitated and more filamentous actin formed in polymerizing conditions. The possible mode of methylglyoxal action is discussed. |
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