Prostaglandin F2a inhibition of epinephrine stimulated cyclic AMP and progesterone production by rat corpora lutea of various ages |
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Authors: | Kurt Ahrn Ensio Norjavaara Sten Rosberg Gunnar Selstram |
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Institution: | 1. Department of Physiology, University of Götenberg, Box 33031, S-400 33 Götenberg, Sweden;2. Department of Physiology, University of Umeå, 901 87 Umeå, Sweden |
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Abstract: | Epinephrine can mimic the stimulatory effects of LH in vitro on cyclic AMP (cAMP) and progesterone production by isolated rat corpora lutea. The aim of the present study was to test whether the effects of epinephrine in vitro on the rat corpus luteum, as with LH, can be inhibited by prostaglandin F2a (PGF2a. The stimulatory effect of epinephrine on tissue levels of cAMP in 1-day-old corpora lutea was not inhibited by PGF2. A dose-dependent inhibition by PGF2a (0.5–50 μM) was seen for 3-day-old corpora lutea and this inhibition could not be overcome by higher concentrations of epinephrine (0.165–165 μM). The stimulation by epinephrine on progesterone production was inhibited by PGF2a (5 μM) in 3- and 5-day-old, but not in 1-day-old corpora lutea. Thus, PGF2a can inhibit the stimulatory effect of epinephrine in 3- and 5-day-old corpora lutea, but not in the newly formed corpora lutea (1-day-old) and PGF2a shows in this respect the same agedependent inhibitory pattern as in relation to LH stimulation. |
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