1-Aminoindanes as novel motif with potential atypical antipsychotic properties |
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Authors: | Graham James M Coughenour Linda L Barr Bridget M Rock David L Nikam Sham S |
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Institution: | Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. jamesgraha@gmail.com |
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Abstract: | As part of an on-going effort to investigate the chemical space requirements for D(2)/5-HT(2A) receptor antagonists as atypical antipsychotics, new 1-aminoindanes were synthesized. The replacement of the heterocycle (oxindole) in ziprasidone with a carbocycle (indane) was well tolerated and was found to retain binding affinities for dopamine D(2), serotonin 5-HT(2A), and serotonin 5-HT(1A). Such compounds hold promise as a new chemical motif with atypical antipsychotic properties for the treatment of schizophrenia and related disorders. |
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