Interferon alters the pattern of secreted proteins from Ehrlich ascites-tumour cells. |
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Authors: | S Tominaga and K Tominaga |
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Affiliation: | Okinaka Memorial Institute for Medical Research, Tokyo, Japan. |
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Abstract: | Treatment of Ehrlich ascites-tumour (EAT) cells with interferon (IFN) abolished their ability to secrete a 32 kDa protein that was secreted by growing EAT cells. These IFN-treated cells secreted two proteins (molecular masses 100 and 89 kDa as estimated by SDS/polyacrylamide-gel electrophoresis) that were not detected in two-dimensional gel electrophoresis of the culture fluid of untreated EAT cells. The sequence of 20 amino acids from the N-terminal end of the 32 kDa protein was very similar to portions of sequences of mouse proviral gag proteins. |
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