Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. |
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Authors: | Ravi Malaviya Fatih M Uckun |
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Affiliation: | Department of Allergy, Parker Hughes Institute, 2699 Patton Road, St. Paul, MN 55113, USA. |
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Abstract: | In this study we show that IgE receptor engagement triggers activation of STAT6 in mast cells. We sought to determine the role of STAT6 activation in IgE receptor-mediated mast cell responses using STAT6 knockout mice. After IgE receptor engagement, bone marrow mast cells from STAT6(-/-) mice exhibited normal histamine and leukotriene C(4) release, but their cytokine release was markedly reduced. In accordance with these in vitro data, IgE/Ag-challenged STAT6(-/-) mice showed normal early phase, but severely impaired late phase, allergic reactions. These findings provide unprecedented evidence that STAT6 plays a pivotal role in mast cell responses to IgE/Ag stimulation. |
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