Ion-Ion interactions at the selectivity filter. Evidence from K(+)-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels |
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| Authors: | Immke D Korn S J |
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| Affiliation: | Department of Physiology, University of Connecticut, Storrs, Connecticut 06269, USA. |
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| Abstract: | In the Kv2.1 potassium channel, binding of K(+) to a high-affinity site associated with the selectivity filter modulates channel sensitivity to external TEA. In channels carrying Na(+) current, K(+) interacts with the TEA modulation site at concentrations
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| Keywords: | permeation outer vestibule conformation repulsion |
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