^#Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

^*Laboratory of Clinical Science, NIMH, Bldg. 10, Rm. 3D-48 National Institutes of Health, Bethesda, MD 20205, USA

^†Pharmacology-Toxicology Program National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD 20205, USA

^‡Department of Pharmacology, St. Louis University School of Medicine 1402 S. Grand Blvd., St. Louis, MO 63104, USA

^§The Genesee Hospital, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14607, USA

^¶Department of Neurology, Columbia University, College of Physicians and Surgeons 630 West 168 St., New York, NY 10032, USA

^**Digestive Diseases Branch, NIADD, National Institutes of Health, Bethesda, MD 20205, USA

^***Department of Pediatrics, United States Uniformed Health Services, Bethesda, MD 21045, USA