| 综述与专论: 低功率光照疗法对机体免疫应答的影响 |
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| 引用本文： | 常好才,张真真,刘镭. 综述与专论: 低功率光照疗法对机体免疫应答的影响[J]. 生物化学与生物物理进展, 2017, 44(12): 1074-1082 |
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| 作者姓名： | 常好才 张真真 刘镭 |
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| 作者单位： | 华南师范大学生物光子学研究院激光生命科学研究所，暨激光生命科学教育部重点实验室，广州 510631,中山大学中山医学院人类病毒研究所，广州 510080,华南师范大学生物光子学研究院激光生命科学研究所，暨激光生命科学教育部重点实验室，广州 510631 |
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| 基金项目： | 国家自然科学基金 (61361160414, 31470072, 61405061)和广东省自然科学基金 (2014A030313419)资助项目 |
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| 摘 要： | 最近几年，采用红至红外波长(600～1 100 nm)的低功率光照(low-dose light，LDL)疗法对组织代谢系统、神经系统、血液循环系统和免疫系统等方面的调节效应已经引起了广泛关注．同时，生物能学和光生物学基础研究的发展推动了低功率光照在疾病治疗领域的革新．有报道指出，巨噬细胞、肥大细胞、中性粒细胞和淋巴细胞等免疫细胞能响应低功率光照，产生细胞因子和保护性的蛋白质分子来缓解一些疾病的进程．因此，本文将从分子、细胞和组织水平对低功率光照改善的一些疾病的免疫学现象及机制进行归纳总结．
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| 关 键 词： | 低功率光照，炎症反应，淋巴水肿，口咽黏膜炎，辐射性皮炎，抗肿瘤和抗菌 |
| 收稿时间： | 2017-07-13 |
| 修稿时间： | 2017-09-18 |
Reviews and Monographs: Low-dose Light Therapy on Host Immune Response: Physiological Effects and Mechanisms of Action |
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| CHANG Hao-Cai,ZHANG Zhen-Zhen and LIU Lei. Reviews and Monographs: Low-dose Light Therapy on Host Immune Response: Physiological Effects and Mechanisms of Action[J]. Progress In Biochemistry and Biophysics, 2017, 44(12): 1074-1082 |
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| Authors: | CHANG Hao-Cai ZHANG Zhen-Zhen LIU Lei |
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| Affiliation: | MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China,Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University North Campus, Guangzhou 510080, China and MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China |
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| Abstract: | The effect of low-dose light (LDL) therapy, commonly using red and near infrared (NIR) light (600-1 100 nm), has gained attention in recent years as a relatively noninvasive technique in modulating the tissue metabolic system, nervous system, blood circulation system and immune system. The progress in the basic science fields of bioenergetics and photobiology has propelled LDL into the therapeutic revolution. The immune cells including macrophages, mast cells, neutrophils and lymphocytes as responder cells by LDL have been studied in the animals and humans with producing cytokines and protective proteins. The paper will review the mechanisms of immune action of LDL at the molecular, cellular, and tissue levels on mammalian. |
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| Keywords: | Low-dose light inflammatory reaction lymphedema oropharyngeal mucositis radiation dermatitis anti-infection and anti-tumor |
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