Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality. |
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| Authors: | G D Wallace R M Buller and H C Morse rd |
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| Institution: | G D Wallace, R M Buller, and H C Morse, 3rd |
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| Abstract: | Resistance to ectromelia (mousepox) virus-induced mortality was examined in crosses between susceptible DBA/2J, A/J, and BALB/cByJ mice and resistant C57BL/6J and AKR/J mice. Depending on the cross, resistance to mousepox virus was shown to be determined by one or more independently assorting autosomal loci with dominant alleles for resistance in AKR/J and C57BL/6J mice and recessive alleles in A/J, BALB/cByJ, and DBA/2J mice. A sexual dimorphism in resistance to disease was also observed. |
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