Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones |
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| Authors: | Ishar M P S Raj Tilak Agrawal Satyam Kumar Saxena A K Singh Lakhwinder Singh Rajinder Bhella Surinderjit Singh |
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| Institution: | aBio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India;bPharmacology Division, Indian Institute of Integrative Medicine, Jammu 180 001, J&K, India |
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| Abstract: | Baeyer–Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo5.4.0.03,6]-undec-1-en-4-ones 4a–h by H2O2 and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-1,2-c]furan-1-ones 8a–h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-1,2-c]furan-2-ones 9a–h in high yields. The obtained butyrolactones 8a–h display cytotoxic activity against a number of human cancer cells. |
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| Keywords: | Photocycloadditions DNA topoisomerase inhibitors Baeyer– Villiger oxidation γ -Butyrolactone Anticancer activity |
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