Toll样受体与树突状细胞介导的天然免疫和获得性免疫

树突状细胞(dendritic cells,DCs)作为迄今所发现的抗原提呈功能最强的一类抗原提呈细胞,是联结天然免疫和获得性免疫的桥梁。Toll样受体(Toll-like receptors,TLRs)是一类进化保守的胚系编码的模式识别受体,在DCs的抗原识别、递呈及激活T细胞等方面具有重要作用,是机体受外来抗原入侵后作出适当免疫反应的调控点。现就TLRs在不同DCs亚群中的分布、与DCs介导的天然免疫和获得性免疫的关系及DCs功能可塑性的分子基础作一综述。

Toll-like Receptors and The Innate Immunity and Adaptive Immunity Mediated by Dendritic Cells

Dendritic cells (DCs), the most potent antigen-presenting cells (APC) which have been explored so far, play crucial roles in innate and adaptive immune response. Toll-like receptors (TLRs) are a group of conservative pattern-recognition receptors (PRR) in embryogenesis. They play an important role in the antigen recognition and presentation as well as in activation na?ve T cells by DCs. Moreover, they are also the check-points in regulating immunity when the host encounters antigens. This review will focus on the distribution of TLRs in different DCs subsets, the interactions with the innate immunity or adaptive immunity mediated by DCs, and the molecular basis of DCs functional plasticity.