靶向肿瘤治疗的腺相关病毒载体

靶向性是肿瘤治疗取得成功的关键因素。病毒载体用于治疗肿瘤的过程中必须要求特异性作用于肿瘤细胞的同时降低对正常细胞的毒性。腺相关病毒(adeno-associated virus,AAV)较其他病毒载体具有免疫原性小、宿主范围广和介导基因可长期表达等优点,因此得到了广泛的应用。然而,AAV载体针对肿瘤的靶向性一直是近年研究的热点和难点。现就AAV载体治疗肿瘤的概况和靶向策略以及其安全性等方面作一综述。

Targeting Cancer Therapy of Adeno-associated Virus Vector

Targeting is the key point of success in cancer therapy. Cancer therapy based on virus vector must require specifically act on tumor cells meanwhile reducing the cytoxicity to the normal cells. Adeno-associated virus (AAV) vectors are widely used in treatment of human disease with the advantage of their low immune response, broad host range, and persistent and stable gene expression compared with other virus vectors. However, targeting cancer therapy mediated by AAV vectors still becomes the recent hot and difficult problem. In this review, we will focus on cancer therapy profile, recent progress in targeting strategies and the safety in the use of AAV vectors.