The regulation and functional impact of actin assembly at cadherin cell–cell adhesions |
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| Institution: | 1. Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia;2. Department of Mechanical & Aerospace Engineering, Old Dominion University, Norfolk, Virginia;1. Department of Psychiatry, Program in Neuroscience, Rock Hall, University of California at San Francisco, San Francisco, CA 94158-2324, USA;2. Division of Bioinformatics, Department of Biology, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany;3. Department of Functional Genomics, MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;4. U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA;5. Center for Neuroscience, University of California Davis, Davis, CA 95618, USA;6. PLOS, 1160 Battery Street, San Francisco, CA 94111, USA;7. Department of Anatomy, Faculty of Medicine, University Murcia E-30100 and IMIB (Instituto Murciano de Investigación Biosanitaria), 30100 Murcia, Spain;8. Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA;9. Acetylon Pharmaceuticals Inc., Boston, MA 02210, USA;10. Allen Institute for Brain Science, Seattle, WA 98103, USA;11. School of Natural Sciences, University of California, Merced, CA 95343, USA;1. Department of Systems Biophysics, FOM Institute AMOLF, Amsterdam, The Netherlands;2. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;3. Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands;4. Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | Cadherin adhesion receptors are critical components for the maintenance of tissue architecture and organisation during development and in post-embryonic life. These receptors influence the actin cytoskeletal network by controlling its assembly at the junctions. Likewise, the actin cytoskeleton is required for cadherin integrity at cell–cell contacts. The junctional cytoskeleton is intrinsically dynamic and undergoes constant assembly and reorganisation to maintain a morphologically stable structure. This is governed by a host of molecular players that regulate actin assembly during nucleation and at post-nucleation stages. This review highlights the molecular machinery implicated in actin organisation at various stages of junctional assembly and its functional impact in simple epithelia and other model systems. |
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