Clawing back: broadening the notion of metal chelators in medicine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Clawing back: broadening the notion of metal chelators in medicine

Institution:	1. Faculty of Science, Chemistry Department, Alexandria University, Ibrahimia, P.O. Box 426, Alexandria 21321, Egypt;2. Thin Film Laboratory, Physics Department, Faculty of Education, Ain Shams University, Heliopolis, Roxy, Cairo 11757, Egypt;3. Advanced Technology and New Materials Institute, City for Scientific Research and Technology Applications, Alexandria, Egypt

Abstract:	Download : Download high-res image (185KB) Download : Download full-size image Highlights► Not all chelators are the same: more than metal sequestration and elimination. ► Metal chelates can redistribute metals across biological membranes. ► Metal-chelating fragments provide leads for metalloenzyme inhibition. ► Metal chelation can enhance metal reactivity and thus cytotoxicity. ► Prochelators provide site-activated metal chelation and passivation.

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