Notch signaling during cell fate determination in the inner ear |
| |
| Institution: | 1. Department of Ophthalmology, University of Rochester, Rochester, NY 14642, United States;2. Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, United States;1. University of Washington School of Medicine and the Virginia Merrill Bloedel Hearing Research Center, Seattle, WA, United States;2. Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States;3. Oregon Health Sciences University, Portland, OR, United States;4. Department of Otolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China;1. Laboratory of Inner Ear Research, Department of Biomedical Research, University of Bern, Switzerland;2. Dept. of Clinical Neurosciences, Service of Otorhinolaryngology and Head & Neck Surgery, Hôpitaux Universitaires de Genève, Switzerland;3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA;4. Dept. of Otolaryngology, Head & Neck Surgery, Stanford University School of Medicine, CA, USA;5. Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, Switzerland;1. MOE Key Laboratory of Model Animal for Disease Study, Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing 210032, China;2. Research Institute of Otolaryngology, No. 321 Zhongshan Road, 210008 Nanjing, China;3. Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210032, China;4. Institute for Brain Sciences, Nanjing University, Nanjing 210032, China |
| |
| Abstract: | In the inner ear, Notch signaling has been proposed to specify the sensory regions, as well as regulate the differentiation of hair cells and supporting cell within those regions. In addition, Notch plays an important role in otic neurogenesis, by determining which cells differentiate as neurons, sensory cells and non-sensory cells. Here, I review the evidence for the complex and myriad roles Notch participates in during inner ear development. A particular challenge for those studying ear development and Notch is to decipher how activation of a single pathway can lead to different outcomes within the ear, which may include changes in the intrinsic properties of the cell, Notch modulation, and potential non-canonical pathways. |
| |
| Keywords: | Notch Inner ear Hair cell Cochlea Otic vesicle Jagged |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
