Vaccine design: emerging concepts and renewed optimism
Institution:
1. Thayer School of Engineering, Dartmouth College, NH, USA;2. Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, NH, USA;1. Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran;2. Biology Research Center, Faculty of Basic Sciences, Imam Hossein University, Tehran, Iran;3. Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran;1. Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata 700068, India;2. Physics Department, Jadavpur University, Kolkata 700032, India;3. Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, West Bengal, India;1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
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Highlights► Highly variable and complex pathogens remain challenging vaccine targets. ► Systems biology and reverse vaccinology continue to foster success. ► New ways of presenting conserved, functionally critical epitopes hold promise. ► Adjuvant systems allow for enduring, native antigen presentation. ► An ideal vaccine provides synergy between innate, cellular, and humoral immunity.
