Nutrient and chemical sensing by intestinal pathogens |
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| Institution: | 1. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA;2. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA;1. Institute of Theoretical Physics, University of Tokushima, Tokushima 770-8502, Japan;2. Department of Information and Computer Engineering, Okayama University of Science, Okayama 700-0005, Japan;1. Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte (MG), Brazil;2. Fundação de Medicina Tropical Dr. Heitor Viera Dourado, Amazonas, Manaus, Brazil;1. Department of Vaccinology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan;2. Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan |
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| Abstract: | Pathogenic gut bacteria, such as those comprising the Enterobacteriaceae family, have evolved sophisticated virulence mechanisms, including nutrient and chemical sensing, to escape host defense strategies and produce disease. In this review we describe the mechanisms utilized by the enteric pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 to achieve successful colonization of its mammalian host. |
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| Keywords: | Enterobacteriaceae Signals Type-III secretion Two-component system |
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