New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris
Institution:
1. Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, Graz A-8010, Austria;2. Sandoz GmbH, Biochemiestrasse 10, A-6250 Kundl, Austria;3. Austrian Centre of Industrial Biotechnology (ACIB GmbH), Petersgasse 14, Graz A-8010, Austria
Abstract:
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Highlights► The application of Pichia pastoris for biopharmaceutical production is described. ► Synthetic biology approaches and perspectives to improve production are reviewed. ► Glycoengineering efforts to produce humanized, uniform glycoproteins are covered. ► The design and application of synthetic promoter variants are highlighted. ► The molecular toolbox available for synthetic biology in P. pastoris is discussed.
