Mathematical analysis and modeling of motion direction selectivity in the retina |
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Affiliation: | 1. Universidad Técnica Federico Santa María, Department of Electronics Engineering, Avda España 1680, Valparaíso, Chile;2. Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Pje Harrington 287, Valparaíso, Chile;3. Facultad de Ciencias, Universidad de Valparaíso, Avda Gran Bretaña 1111, Valparaíso, Chile |
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Abstract: | Motion detection is one of the most important and primitive computations performed by our visual system. Specifically in the retina, ganglion cells producing motion direction-selective responses have been addressed by different disciplines, such as mathematics, neurophysiology and computational modeling, since the beginnings of vision science. Although a number of studies have analyzed theoretical and mathematical considerations for such responses, a clear picture of the underlying cellular mechanisms is only recently emerging. In general, motion direction selectivity is based on a non-linear asymmetric computation inside a receptive field differentiating cell responses between preferred and null direction stimuli. To what extent can biological findings match these considerations? In this review, we outline theoretical and mathematical studies of motion direction selectivity, aiming to map the properties of the models onto the neural circuitry and synaptic connectivity found in the retina. Additionally, we review several compartmental models that have tried to fill this gap. Finally, we discuss the remaining challenges that computational models will have to tackle in order to fully understand the retinal motion direction-selective circuitry. |
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Keywords: | Motion direction selectivity Retina Direction-selective retinal ganglion cell Starburst amacrine cell Computational model Compartmental model |
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