Expanded genetic code for the engineering of ribosomally synthetized and post-translationally modified peptide natural products (RiPPs)
Institution:
2. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States
Abstract:
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Highlights► RiPPs have high capabilities of target interaction far beyond the field of anti-infectives. ► RiPPs are especially suitable for design and engineering with the genetic code expansion. ► First published studies yielded RiPPs with unnatural/synthetic amino acids. ► Achievement: expanded scope of the in vivo (mainly bacterial) RiPPs synthesis. ► Perspective: design of RiPPS with novel chemistries and unique sequence combinations.
