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Deciphering the bacterial glycocode: recent advances in bacterial glycoproteomics
Affiliation:1. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Department of Pathobiology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Microbiology and Immunobiology, 4 Blackfan Circle, Boston, MA 02115, USA;2. Department of Biochemistry and Molecular Biology, 206 South Frear Laboratory, University Park, PA 16802, USA;3. From the Chemical and Biological Engineering;;4. Clinical & Translational Research Center;;5. Pharmaceutical Sciences; and;6. New York State Center for Excellence in Bioinformatics and Life Sciences, Buffalo, New York;1. Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA;2. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
Abstract:.
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  • Highlights► Bacterial glycoproteins are potential drug targets and are worthy of study. ► Metabolic glycan labeling enables discovery and characterization of glycoproteins. ► Lectin arrays permit monitoring of bacterial glycoprotein dynamics. ► Crosslinking sugars reveal binding partners of glycoproteins to elucidate function. ► Bacterial glycosylation systems facilitate efficient glycoprotein production.
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