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Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials
Institution:1. Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721, United States;2. NCI-designated University of Arizona Comprehensive Cancer Center, Tucson, Arizona, 85721, United States;3. Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, 85721, United States;4. BIO5 Institute, The University of Arizona, Tucson, Arizona, 85721, United States;1. School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China;2. Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China;3. Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China;4. Aix-Marseille Université, CNRS, Center Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisé par La Ligue, Marseille 13288, France;5. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China;6. Molecular Biology and Nanotechnology Laboratory, Department of Engineering and Architecture, University of Trieste, Trieste 34127, Italy;7. Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-236, Poland
Abstract:
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  • Highlights► Development of prodrug-based self-assembled hydrogels as a new class of biomaterials. ► Design of prodrugs that can self-assemble to form hydrogels. ► These hydrogels overcome limitations such as low-drug loading and burst release of drugs. ► Locally injectable self-assembled hydrogels exhibit potential as effective therapeutics.
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