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The role of diet in triggering human inflammatory disorders in the modern age |
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| Affiliation: | 1. Research Laboratory in Applied Immunology, State University of Londrina, Londrina, Brazil;2. Department of Rheumatology, State University of Londrina, Londrina, Brazil;3. Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Brazil;4. Department of Internal Medicine, University of Londrina, Londrina, Brazil |
| Abstract: | Previously uncommon human inflammatory disorders are emerging with alarming frequency, possibly triggered by environmental factors introduced through Westernization. This review highlights how Western diets heighten the inflammatory state promoting development of disease. Evidence that this can occur directly or indirectly through perturbations of host–microbe interactions are reviewed. |
| Keywords: | Gut microbiota Western diet High-fat Inflammatory disease Systemic inflammation Immunity |
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