Influence of recipient and donor IL-10, TNFA and INFG genotypes on the incidence of acute renal allograft rejection |
| |
Authors: | Negar Azarpira Mahdokht H Aghdai Ghanbar A Raisjalali Masumeh Darai Moham J Tarahi |
| |
Institution: | (1) Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351 Shiraz, Iran;(2) Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran;(3) Gastroentrology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
| |
Abstract: | Objective Transplantation of renal grafts is an established treatment for renal failure in a variety of medical conditions. Acute allograft
rejection remains an important cause of morbidity after kidney transplantation, and has been shown to be a crucial determinant
of long-term graft function. Although rejection is mediated by recipient lymphocytes, both donor and recipient factors contribute
to the local environment that influences the severity of rejection response. Because cytokines are the main components of
immune responses, we evaluate single nucleotide polymorphisms (SNP) of several cytokine genes that may influence the production
of a given cytokine and therefore the features of immune reactions. Material and Methods The aim of this study was to determine the impact of the cytokine gene polymorphism of pro and anti-inflammatory cytokines
on the development of acute allograft rejection, which could be used in pretransplant patient assessment. Three SNPs including
IL-10 (−1082 G/A), TNFA (−308 G/A), and INFG (+874 T/A) were analyzed in 46 patients with acute allograft rejection, 54 patients
with stable graft function and their kidney donors by PCR-ARMS method. Results We are unable to find statistically significant association between any of the studies polymorphisms and clinical outcomes.
Conclusion We have found no evidence to suggest that either recipient or donor cytokines polymorphisms determine the incidence of acute
rejection after renal transplantation. Our observation, however, is based on few cases, and this may mask a possible favorable
effect. It is recommended that several functionally related genes should be tested in similar studies, since this approach
has a higher chance to detect genetic risk factors than the screening of single genetic variants. |
| |
Keywords: | Donor Recipient Cytokine gene polymorphism Renal transplantation Rejection |
本文献已被 PubMed SpringerLink 等数据库收录! |
|