Phylogenetic analysis of RhoGAP domain-containing proteins |
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Authors: | Brandão Marcelo M Silva-Brandão Karina L Costa Fernando F Saad Sara T O |
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Institution: | aHematology and Hemotherapy Center, State University of Campinas, 13083-970 Campinas, SP, Brazil;bDepartment of Zoology, Institute of Biology, State University of Campinas, 13083-970 Campinas, SP, Brazil |
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Abstract: | Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions. The abil- ity of these GTPases to regulate a wide number of cellular processes comes from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing proteins. The sequences were aligned by their RhoGAP do- mains and the phylogenetic hypotheses were generated using Maximum Parsimony and Bayesian analyses. The character tracing of two traits, GTPase activity and presence of other domains, indicated a significant phylogenetic signal for both of them. |
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Keywords: | Bayesian analysis character tracing parsimony phylogenomics protein domain RhoGAP |
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