Detection of <Emphasis Type="Italic">Candida</Emphasis><Emphasis Type="Italic">dubliniensis</Emphasis> in Venezuela |
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Authors: | Email author" target="_blank">Claudia?Hartung?de? CaprilesEmail author Sofía?Mata-Essayag Celina?Pérez Maria?Teresa?Colella Arantza?Roselló Carolina?Olaizola Sylvia?Magaldi?Teresa?Abate |
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Institution: | (1) Sección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de, Venezuela;(2) Sección de Biología Molecular, Instituto de Medicina Tropical, Universidad Central de, Venezuela;(3) Sección de Micología Médica, Instituto de Medicina Tropical, Ciudad Universitaria, Los Chaguaramos, Apartado Postal 47423, Caracas, 1041, Venezuela |
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Abstract: | Over the past decades there has been a significant increase in fungal infections caused by Candida species, and continues to be common in immunocompromised individuals infected with the human immunodeficiency virus (HIV).
Although Candida albicans remains the fungal species most frequently isolated as an opportunistic oral pathogen, other non-albicans are often identified in this cohort of patients, including C. dubliniensis. This yeast is closely related to and shares many phenotypic characteristics with C. albicans. Colonies of these two species appear morphologically identical when not grown on special media. The shared phenotypic characteristics
of C. dubliniensis and C. albicans suggest that many C. dubliniensis isolates may have been misidentified as C. albicans in the past. The present studies aim is to recover and identify C. dubliniensis, and presumptive clinical C. albicans, from the oral cavities of HIV-seropositive individuals, comparing conventional media to obtain a simple, low-cost and reliable
identification system for C. dubliniensis. A total of 16 isolates (3,98%) had been obtained from 402 HIV infected individuals with recurrent oropharyngitis and were
identified as C. dubliniensis. Out of these C. dubliniensis isolates 19% were resistant, with MICs above 64 μg/ml to fluconazole. This constitutes, to the authors knowledge the first
recovery of this organism in Venezuela. |
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Keywords: | C dubliniensis phenotypic genotypic HIV Venezuela |
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