Praziquantel derivatives I: Modification of the aromatic ring |
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Authors: | Ronketti Fiona Ramana A Venkata Chao-Ming Xia Pica-Mattoccia Livia Cioli Donato Todd Matthew H |
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Affiliation: | School of Biological and Chemical Sciences, Queen Mary, University of London, E1 4NS, UK. |
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Abstract: | Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis. |
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