Non-detection of human herpesvirus 8 (HHV-8) DNA in HHV-8-seropositive blood donors from three Brazilian regions |
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| Authors: | Levi José Eduardo Nascimento Maria Claudia Sumita Laura Masami de Souza Vanda Akico Ueda Fick Freire Wilton S Mayaud Philippe Pannuti Claudio S |
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| Affiliation: | 1. Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil.; 2. Departamento de Moléstias Infecciosas e Parasitárias (LIM 52 -HC), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; 3. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.;University of Cape Town, South Africa |
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| Abstract: | Human herpesvirus 8 (HHV-8), also known as Kaposi''s sarcoma-associated herpesvirus (KSHV), is the etiologic agent of all forms of Kaposi''s sarcoma, primary effusion lymphoma and the plasmablastic cell variant of multicentric Castleman disease. In endemic areas of sub-Saharan Africa, blood transfusions have been associated with a substantial risk of HHV-8 transmission. By contrast, several studies among healthy blood donors from North America have failed to detect HHV-8 DNA in samples of seropositive individuals. In this study, using a real-time PCR assay, we investigated the presence of HHV-8 DNA in whole-blood samples of 803 HHV-8 blood donors from three Brazilian states (São Paulo, Amazon, Bahia) who tested positive for HHV-8 antibodies, in a previous multicenter study. HHV-8 DNA was not detected in any sample. Our findings do not support the introduction of routine HHV-8 screening among healthy blood donors in Brazil. (WC = 140). |
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