The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates |
| |
| Authors: | Mario Débora Alves Nunes Denardi Laura Bedin Bandeira Laíssa Arévalo Antunes Milene Silva Santurio Janio Morais Severo Luiz Carlos Alves Sydney Hartz |
| |
| Institution: | Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. debora_alves6@hotmail.com |
| |
| Abstract: | The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
