Effect of rice--glycerol complex medium on the production of Lovastatin by Monascus ruber |
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| Authors: | Chang Y N Lin Y C Lee C C Liu B L Tzeng Y M |
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| Institution: | (1) Department of Food Engineering, Da-Yeh University, 515 Changhua, Taiwan, Republic of China;(2) Tanque Co., 520 Changhua, Taiwan, Republic of China;(3) Department of Applied Chemistry, Chaoyang University of Technology, 413 Taichung, Taiwan, Republic of China |
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| Abstract: | Response surface methodology (RSM) was employed to study the effect of the composition of the rice-glycerol complex medium
on the production of lovastatin (Lvs) by the ascomyceteMonascus ruber in mixed solid-liquid (or submerged) cultures at 25°C. Four components (rice powder, peptone, glycerol, glucose) were studied
to evaluate, the approximate polynomial for all dependent variables, explaining their effects on the production of Lvs. The
best composition derived from RSM regression was (in g/L) rice powder 34.4, peptone 10.8, , glucose 129, KNO3 8.0, MgSO4·7H2O 4.0 and glycerol 36.4 mL/L. With this composition, the Lvs production was 157 mg/L after 10 d of cultivation. In comparison
with glycerol and glucose, the rice powder becomes a more suitable carbon source and represents a great potential for the
production of Lvs. |
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