Essential ingredients for HIV-1 budding |
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| Authors: | Weissenhorn Winfried Göttlinger Heinrich |
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| Institution: | UVHCI UMI 3265 University Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France. weissenhorn@embl.fr |
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| Abstract: | HIV-1 engages the cellular ESCRT-III/VPS4 membrane scission machinery for its escape from host cells. Three papers now begin to demystify its mode of action by showing that HIV-1 requires only the transient recruitment of a surprisingly small subset of ESCRT-III components, whose membrane abscission function depends on VPS4 activity. |
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