The meaning of alignment: lessons from structural diversity |
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Authors: | Walter Pirovano K Anton Feenstra Jaap Heringa |
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Affiliation: | (1) Centre for Integrative Bioinformatics VU (IBIVU), VU University Amsterdam, De Boelelaan 1081A, 1081HV Amsterdam, the Netherlands |
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Abstract: | Background Protein structural alignment provides a fundamental basis for deriving principles of functional and evolutionary relationships. It is routinely used for structural classification and functional characterization of proteins and for the construction of sequence alignment benchmarks. However, the available techniques do not fully consider the implications of protein structural diversity and typically generate a single alignment between sequences. |
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