主要组织相容性复合体I类分子抗原肽

被主要组织相容性复合体(MHC)I类分子呈递在细胞表面的抗原肽大部分来源于细胞内新合成蛋白质的降解产物,抗原肽直接体现细胞内功能蛋白质的部分变化,蛋白酶体、氨肽酶和抗原转运体(TAP)参与调控抗原肽的生成。在MHC的组装、折叠过程中,抗原肽促进各亚基的结合和折叠进程;而在起始细胞的免疫应答过程中,抗原肽不仅诱导T细胞抗原受体的特异结合,更为重要的是延长MHC同T细胞抗原受体特异结合的作用时间。

Antigenic Peptides Bound to MHC Class I Molecule

the antigenic peptide binding with major histocompatibility complex ( MHC ) class I molecules at the cell surface directly reflect the changing of protein in the cell, the antigenic peptide advance the assembly and export of MHC class I complex in ER, and stable the association of MHC class I complex and TCR; the antigenic peptide is partly from the degradation of new synthetic endogenous proteins by proteasome and some peptidases, the characteristics of the peptide transporter associated with antigen processing (TAP) modulate the specificity of the antigenic, as well as MHC class I molecule.