Fructose-1, 6-bisphosphatase in human fetal brain and liver during development |
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| Authors: | Tapas Biswas Arun Lahiri Majumder Gitanjali Guha Thakurta K L Mukherjee |
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| Institution: | (1) Biochemistry Laboratory, Department of Botany, School of Life Sciences, Visva-Bharati, 731235 Santiniketan;(2) Department of Biochemistry, Institute of Post Graduate Medical Education and Research, 700 020 Calcutta |
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| Abstract: | Activity of fructose-1,6-bisphosphatase (EC 3.1.3.11), one of the key gluconeogenic enzymes, was measured in human fetal brain
and liver during development. Fructose-1,6-bisphosphatase was distributed throughout the different regions of the brain. In
contrast to the partially purified enzyme from the brain, the liver enzyme was dependent on Mg2+ for maximal activity, EDTA, citrate, oleate and linoleate were stimulatory, whereas 5′-AMP inhibited the activity of the
liver enzyme. |
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| Keywords: | Human fetus brain and liver fructose bisphosphatase fructose-phosphate interconversion myo— inositol synthesis |
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