| Rho/ROCK信号通路与神经可塑性 |
| |
| 引用本文： | 陈琪,贾瑞丹,陈霏霏,杨丽,李怡瑞.Rho/ROCK信号通路与神经可塑性[J].生命的化学,2019(1):159-164. |
| |
| 作者姓名： | 陈琪 贾瑞丹 陈霏霏 杨丽 李怡瑞 |
| |
| 作者单位： | 陕西师范大学西北濒危药材资源开发国家工程实验室药用植物资源与天然药物化学教育部重点实验室生命科学学院 |
| |
| 摘 要： | 在神经网络中,神经可塑性是大脑响应内在和外在刺激的重要特征。越来越多的研究已经阐明了神经可塑性与神经损伤性疾病之间的相关性。Rho/Rho相关卷曲螺旋形成蛋白激酶(Rho/Rho associ-ated coiledcoil forming protein kinase, Rho/ROCK)通路是生物体广泛存在的经典信号通路,参与细胞迁移、树突发育和轴突延伸,并且与帕金森、精神发育迟滞和阿尔茨海默症等多种神经退行性或损伤性疾病有关。本文对Rho/ROCK信号通路与神经可塑性的研究进展予以综述,讨论了ROCK抑制剂对各种神经疾病的潜在治疗前景。
|
| 关 键 词： | RHO ROCK 神经可塑性 ROCK抑制剂 |
Rho/ROCK signaling pathway and neural plasticity |
| |
| CHEN Qi,JIA Ruidan,CHEN Feifei,YANG Li,LI Yirui.Rho/ROCK signaling pathway and neural plasticity[J].Chemistry of Life,2019(1):159-164. |
| |
| Authors: | CHEN Qi JIA Ruidan CHEN Feifei YANG Li LI Yirui |
| |
| Institution: | (Key Laboratory of the Ministry of Education for Medici nal Resources and Natural Pharmaceutical Chemistry,National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China,College of Life Sciences,Shaanxi Normal University,Xi'an 710119,China) |
| |
| Abstract: | CHEN Qi;JIA Ruidan;CHEN Feifei;YANG Li;LI Yirui(Key Laboratory of the Ministry of Education for Medici nal Resources and Natural Pharmaceutical Chemistry,National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China,College of Life Sciences,Shaanxi Normal University,Xi'an 710119,China) |
| |
| Keywords: | Rho ROCK neural plasticity ROCK inhibitor |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
